BPC-157 5 mg

What Is BPC-157 and What Does It Do?

Body Protection Compound 157 (BPC-157) is a synthetic peptide chain consisting of 15 amino acids. Originally isolated from a protein found in human gastric juice, this peptide has attracted significant attention in preclinical research due to its potential roles in supporting tissue repair and cellular integrity.

To be clear, any claims regarding therapeutic benefits are based on preliminary findings in non-human models. However,  numerous in vivo and in vitro studies have investigated BPC-157’s effects on musculoskeletal tissue, including tendons, ligaments, and muscles, as well as its potential influence on the central nervous system, vascular regeneration, and gastrointestinal function.

Research suggests that BPC-157 may promote angiogenesis (formation of blood vessels), modulate inflammatory responses, and support the body’s natural healing mechanisms at the cellular level—though these effects remain under investigation.

Observed Effects of BPC-157 in Preclinical Healing Studies

In laboratory and animal studies, BPC-157 has demonstrated a wide range of biological activities that may support healing and tissue regeneration. While clinical research is still lacking, preclinical models suggest that BPC-157 may influence several key systems involved in recovery and cellular repair.

Some of the observed effects include:

Accelerated Wound Healing

In preclinical studies, BPC-157 has demonstrated impressive wound healing properties, particularly in models of chemical burns and soft tissue damage. It appears to stimulate the formation of granulation tissue, reepithelialization, and collagen deposition—key phases in the healing process.

Additionally, BPC-157 promotes angiogenesis, or the development of new blood vessels, which is crucial for delivering nutrients and oxygen to damaged tissue.

This compound may also enhance the migration and proliferation of endothelial cells, further aiding tissue regeneration. These effects make it a promising candidate for future studies on complex wound healing scenarios.

Tendon and Ligament Recovery

Animal studies suggest that BPC-157 plays a unique role in supporting the repair of ligaments and tendons, which traditionally suffer from poor blood supply and slow recovery. Research shows that BPC-157 may activate healing cascades that improve fibroblast activity, collagen fiber organization, and functional recovery in tendon rupture and ligament injury models.

These modes of healing have been observed in rodents with transected Achilles tendons. The peptide also seems to counteract the damaging effects of nonsteroidal anti-inflammatory drugs (NSAIDs) and may protect connective tissues from further breakdown.

These findings point to BPC-157’s potential as a research tool in studying recovery from sports injuries and repetitive strain conditions.

Muscle and Bone Repair

In preclinical studies, BPC-157 has shown the ability to support muscle regeneration and bone healing. Research suggests it can enhance fibroblast activity, promote vascularization, and increase the expression of genes involved in tissue growth and remodeling.

Notably, it may also help reverse muscle wasting and improve functional recovery in cases of injury. For bone tissue, BPC-157 appears to stimulate osteoblast activity and speed up fracture healing, even in compromised conditions like steroid-induced damage. These findings make it a promising peptide for further exploration in musculoskeletal research.

Gastrointestinal Support

BPC-157 originally drew attention for its protective effects on the gastrointestinal tract. In rodent studies, it has shown the ability to accelerate the healing of ulcers, reduce inflammation, and protect the intestinal lining from NSAID-induced damage.

It seems to help maintain gut integrity by preserving endothelial function and tight junctions, crucial for a healthy barrier against pathogens and toxins. Additionally, BPC-157 may counteract the effects of harmful agents like alcohol or toxins in the stomach and colon, making it valuable in GI-related research.

Neuroprotective Properties

Preclinical data suggests BPC-157 may play a neuroprotective role, aiding in nerve regeneration and recovery from central nervous system damage. In rodent studies, it has been shown to support healing after traumatic brain injury, spinal cord injury, and peripheral nerve damage.

BPC-157 may influence neurotransmitter systems, including dopamine and serotonin pathways, and may reduce oxidative stress in neural tissue. These findings point to its potential in research related to neural repair, neurodegeneration, and stroke recovery—though human applications remain entirely unstudied at this time.

Anti-Inflammatory Activity

BPC-157 has demonstrated potent anti-inflammatory effects in a variety of animal models. It appears to modulate the immune response by influencing cytokine activity and suppressing pro-inflammatory signaling.

In studies of inflammatory bowel disease, soft tissue injury, and even arthritis-like conditions, the peptide has reduced swelling, limited tissue degradation, and improved healing environments. It also seems to stabilize nitric oxide pathways, which are key to maintaining vascular health and controlling inflammation. These properties make BPC-157 a valuable compound for ongoing inflammation-related research.

Evolve Peptides Sets the Standard on Peptide Purity & Quality Control

At Evolve Peptides, we understand that purity and quality are non-negotiable when you buy BPC-157  research peptides. Even small impurities can introduce variability into test results, compromise reproducibility, or interfere with biological activity. That’s why every step in peptide production matters—from synthesis and filtration to analysis and packaging.

Common methods used to ensure peptide purity include:

• High-Performance Liquid Chromatography (HPLC): Used to verify purity levels and detect contaminants or byproducts.
• Mass Spectrometry (MS): Confirms molecular weight and peptide identity.
• Sterile Filtration: Reduces microbial contamination risk.
• Lyophilization (freeze-drying): Preserves integrity and extends shelf life.

We work closely with trusted peptide manufacturers who adhere to strict industry standards, including cGMP and ISO certifications. Every production run is subject to rigorous internal controls before it even reaches third-party testing. This partnership ensures that the BPC-157 we offer isn’t just pure—it’s consistent, stable, and traceable from synthesis to shipment.

Every batch of Lyophilized BPC 157 for sale undergoes third-party testing, with documented results confirming >99.6% purity. We publish certificates of analysis (COAs) for transparency and accountability. Our peptides are manufactured in ISO-certified facilities under strict quality control protocols, ensuring consistency from batch to batch.

Note: Independent Testing Welcome We proudly support third-party testing by our customers. If you’d like to validate the purity of our BPC-157 through an independent lab, we’ll replace any peptide vials used in the process—free of charge.*

Is Oral BPC-157 Effective?

While much of the early research on BPC-157 has been conducted through injectable administration in animal models, interest in oral administration has grown significantly due to its convenience and ease of use.

Emerging evidence suggests that oral usage of BPC-157 can be effective, particularly because the compound is derived from a naturally occurring peptide in the gastrointestinal system. This origin supports the hypothesis that it can remain stable in the digestive tract and exert therapeutic effects when taken orally. 

Anecdotal reports and limited studies indicate positive effects in inflammation, improving gut health, accelerating healing of tendons and ligaments, and mitigating symptoms of gastrointestinal disorders.

However, it is important to note that comprehensive clinical trials in humans are still lacking, and the bioavailability of orally administered BPC-157 remains a topic of ongoing investigation. When you buy BPC 157 at Evolve Peptides, we expect you to use it for research purposes only and within the recommended guidelines.

Note: While BPC-157 is derived from gastric proteins and appears to be stable in the digestive tract, in clinical settings oral BPC-157  has been taken on an empty stomach to optimize bioavailability and minimize potential interference from food.

BPC-157 Side Effects in Oral Research Use

BPC-157 is generally regarded as having a favorable safety profile, particularly in preclinical studies involving animals. To date, no severe adverse effects have been consistently documented in research settings.

However, due to the limited number of human studies, particularly long-term evaluations, potential side effects cannot be completely ruled out.

Anecdotal reports occasionally include minor issues such as dizziness, nausea, or changes in appetite. In rare cases, users have reported increased energy levels or restlessness, which may be attributed to the compound’s influence on systemic healing processes or neurotransmitter activity.

It is also important to recognize that BPC-157 is not currently approved by the FDA for human use, and products available on the market may vary in purity and potency. For this reason, we encourage you to exercise caution, buy third-party tested products, and consult trusted professionals before use.

BPC-157: Legal Status and Compliance

BPC-157 is not FDA-approved for human consumption or medical treatment. However, it is legal to purchase and possess in the United States for laboratory research purposes. At Evolve Peptides, we are fully compliant with all regulations governing the sale of research peptides.

We fully expect you to use the BPC-157 you buy from Evolve Peptides within those legal boundaries. By buying from us, you agree to not use the product for self-administration or resale for non-research use.

Where to Buy BPC-157

If you’re looking for the best place to buy BPC 157, you’re in the right place. At Evolve Peptides we provide chemist grade BPC-157  at affordable prices. Our products are manufactured in ISO-certified labs under strict quality control measures.

Every batch of BPC157 is third-party tested, and COAs are provided to confirm purity levels above 99%. This ensures every vial you receive meets rigorous quality standards—verified not just by us, but by trusted independent labs—so you can conduct your research with total confidence.

Plus, our fast shipping, excellent customer service, and no-hassle return policy make us a trusted favorite among researchers. Over 86% of orders arrive within 48 hours, and we even replace products used for third-party testing.

When you buy BPC-157 from Evolve Peptides, you’re choosing verified purity, convenience, and research-ready reliability.

BPC-157 FAQs

Can I order BPC-157 in bulk?

Yes! Bulk quantities of BPC-157 are available. Please contact us directly by emailing us at wholesale@evolvepeptides.com for wholesale pricing and custom product needs.

What if I’m not satisfied with my order?

We offer a customer-friendly return and refund policy. If your order arrives damaged or incorrect, we’ll make it right. Simply email us at support@evolvepeptides.com and we’ll respond within 12 hours. 

How should BPC-157 be stored for research use?

Store BPC-157 in a cool, dry place away from light. For short-term storage (up to two weeks), refrigerate at 4°C (-39°F) or colder. For long-term storage, freeze at -18°C (0°F) and use promptly once reconstituted.

Do you provide a Certificate of Analysis (COA) with each order?

Yes, all Evolve Peptides products, including BPC-157, are backed by third-party testing. COAs are provided to confirm purity, identity, and quality, ensuring transparency and research-grade reliability.

References

1. Chang, C.-H., Tsai, W.-C., Lin, M.-S., Hsu, Y.-H., & Pang, J.-H. S. (2010). The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. Journal of Applied Physiology, 109(3), 711–718. https://doi.org/10.1152/japplphysiol.00476.2010

2. T. Huang, K. Zhang, L. Sun, X. Xue, C. Zhang, Z. Shu, N. Mu, J. Gu, W. Zhang, Y. Wang, Y. Zhang, W Zhang. (2015). Body protective compound-157 enhances alkali-burn wound healing in vivo and promotes proliferation, migration, and angiogenesis in vitro. Current Pharmaceutical Design, 21(9), 1121–1125. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425239/doi:10.2147/DDDT.S82030

3. M. Józwiak, M. Bauer, W. Kamysz, P. Kleczkowska (2025). Multifunctionality and Possible Medical Application of the BPC 157 Peptide—Literature and Patent Review. Pharmaceuticals, 18(2), 185. https://doi.org/10.3390/ph18020185

4. U.S. Food & Drug Administration. (n.d.). Certain Bulk Drug Substances for Use in Compounding that May Present Significant Safety Risks. https://www.fda.gov/drugs/human-drug-compounding/certain-bulk-drug-substances-use-compounding-may-present-significant-safety-risks

6. Gojkovic, S., Krezic, I., Kasnik Kovac, K., Malekinusic, D., Vrdoljak, B., & Kolovrat, M. (2020). Pentadecapeptide BPC 157 resolves Pringle maneuver in rats, both ischemia and reperfusion. World Journal of Hepatology, 12(5), 184–206. https://doi.org/10.4254/wjh.v12.i5.184

6. Boban Blagaic, A.² Dobric, I.³ Durasin, T.² Gojkovic, S.² Horvat Pavlov, K.¹ Kokot, A.⁴

Knezevic, M. et al (2021). Stable Gastric Pentadecapeptide BPC 157 and Wound Healing. Frontiers in Pharmacology, 12, 2021. https://doi.org/10.3389/fphar.2021.627533 

7. Seiwerth, S., Milavić, M., Vukojević, J., Gojković, S., Krezić, I., Batelja Vuletić, L., Horvat Pavlov, K., Petrović, A., Sikiric, S., Vraneš, H., Prtoric, A., Žižek, H., Đurašin, T., Dobrić, I., Starešinić, M., Štrbe, S., Knežević, M., Šola, M., Kokot, A., & Sever, M. (2020). Stable gastric pentadecapeptide BPC 157 and wound healing. Frontiers in Pharmacology, 11, 627533. https://doi.org/10.3389/fphar.2020.627533 

8. Vukojević, J., Milavić, M., Perović, D., Ilić, S., Zemba Čilić, A., Đuran, N., Štrbe, S., Zoričić, Z., Filipčić, I., Brečić, P., Seiverth, S., & Sikirić, P. (2022). Pentadecapeptide BPC 157 and the central nervous system. Neural Regeneration Research, 17(3), 482–487. https://doi.org/10.4103/1673-5374.320969 

9. Seiwerth, S., Milavić, M., Vukojević, J., Gojković, S., Krezić, I., Batelja Vuletić, L., Horvat Pavlov, K., Petrović, A., Sikiric, S., Vraneš, H., Prtoric, A., Žižek, H., Đurašin, T., Dobrić, I., Starešinić, M., Štrbe, S., Knežević, M., Šola, M., Kokot, A., & Sever, M. (2021). Stable gastric pentadecapeptide BPC 157 and wound healing. Frontiers in Pharmacology, 12, 627533. https://doi.org/10.3389/fphar.2021.627533 

10. Wang, S.-H., Lin, L.-P., Lin, M.-S., Pang, J.-H. S., & Tsai, W.-C. (2019). BPC 157 promotes skeletal muscle cells migration in association with up-regulation of paxillin and vinculin expression. Taiwan Journal of Physical Medicine and Rehabilitation, 47(1), 21–29. https://doi.org/10.6315/TJPMR.201906_47(1).0003