VIP 10 mg

Vasoactive Intestinal Peptide (VIP) is a 28-amino-acid neuropeptide belonging to the secretin/glucagon peptide family. First isolated from porcine intestine in 1970, it is expressed throughout the central and peripheral nervous systems and is one of the most studied members of its family in the research literature.

Each vial contains 10 mg of lyophilized synthetic VIP, identical in sequence to the human peptide.

Note: VIP is for research use only. Not for human consumption.

VIP Mechanism of Action (Based on Research)

VPAC1 and VPAC2 Receptor Signaling

VIP binds the class B G-protein-coupled receptors VPAC1 and VPAC2, and with lower affinity the PAC1 receptor shared with pituitary adenylate cyclase-activating polypeptide (PACAP). Receptor activation is coupled to adenylate cyclase, and the resulting rise in intracellular cAMP is the signaling event most commonly measured in VIP research.

Smooth Muscle and Vascular Models

The peptide’s name reflects the vascular smooth muscle relaxation first observed in isolated tissue preparations. It remains a standard reference agonist in organ-bath and vascular-ring experiments.

Neuroendocrine and Immune Cell Studies

VIP is expressed by neurons and by several immune cell types, and cell-culture work characterizes its influence on cytokine transcription, circadian-clock gene expression in the suprachiasmatic nucleus, and secretory activity in endocrine tissue.

VIP Research Applications

VIP is used as a reference agonist in receptor pharmacology (VPAC1/VPAC2/PAC1 selectivity studies), in cAMP signaling assays, in circadian-rhythm research, and in non-clinical work on neuro-immune signaling.

VIP Peptide Characteristics

• CAS Number: 37221-79-7
• Amino Acid Sequence: His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH₂ (28 residues, C-terminal amide)
• Molar Mass: approximately 3,326 g/mol
• Synonyms:
  • Vasoactive intestinal polypeptide
  • VIP (human/porcine sequence)
• Vial Contents: 10 mg lyophilized powder
• Storage Recommendations:
  • Lyophilized powder: store at -4 °F (-20 °C) for long-term storage (stable for up to 3 years); short-term storage at 39 °F (4 °C) (up to 2 years). Keep sealed, dry, and away from light.
  • In solution: store at 39 °F (4 °C) for short periods, or at -4 °F (-20 °C) for longer durations. Avoid repeated freeze-thaw cycles. Use sterile technique when handling.

Certificate of Analysis (COA)

Independent third-party testing for this product is in progress. The batch Certificate of Analysis will be published here as soon as it is available. Contact our support team at any time to ask about its status before ordering.

Legal Disclaimer

This product is intended strictly for laboratory research purposes only. It is not approved by the FDA or any other regulatory agency for human consumption, medical use, or veterinary application.

• • Not for diagnostic, therapeutic, or clinical use.
  • Not intended for resale or use in food, drugs, cosmetics, or household items.
• Not intended for ingestion, injection, or application to humans or animals, and should never be used in any form of self-experimentation.

By purchasing from Evolve Peptides, the buyer agrees to use it in accordance with all applicable laws, regulations, and research safety protocols.