Thymosin Alpha-1 10 mg

Thymosin Alpha-1 (Tα1) is a 28-amino-acid peptide first isolated from thymosin fraction 5 of calf thymus tissue in the 1970s. The synthetic form supplied here is identical in sequence to the natural peptide and carries the same N-terminal acetyl group. It is one of the most extensively characterized thymic peptides in the research literature.

This listing is the 10 mg vial. Each vial contains 10 mg of lyophilized Thymosin Alpha-1; the 5 mg size is listed separately.

Note: Thymosin Alpha-1 is for research use only. Not for human consumption.

Thymosin Alpha-1 Mechanism of Action (Based on Research)

Thymosin Alpha-1 is studied chiefly as a modulator of innate and adaptive immune signaling. Its full mechanism is not settled; the observations below recur across the non-clinical literature.

Toll-Like Receptor Signaling

In vitro work with dendritic cells and macrophages describes Thymosin Alpha-1 acting through Toll-like receptors (TLR2 and TLR9 are the most frequently reported), with downstream changes in MyD88-dependent signaling and cytokine transcription.

Dendritic Cell and T-Cell Differentiation

Animal and cell-culture studies report changes in dendritic cell maturation markers and in the differentiation of T-cell subsets following Tα1 exposure, which is the basis for its use as a reference compound in thymic-signaling research.

Cytokine Expression

Several groups have characterized shifts in interleukin and interferon expression in cultured immune cells exposed to the peptide, alongside changes in indoleamine 2,3-dioxygenase activity in dendritic cells.

Thymosin Alpha-1 Research Applications

Thymosin Alpha-1 is used as a tool peptide in studies of thymic function, dendritic cell biology, TLR signaling, and cytokine networks, and as a comparator in research on other thymic and immunomodulatory peptides.

Thymosin Alpha-1 Peptide Characteristics

• CAS Number: 62304-98-7
• Amino Acid Sequence: Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH (28 residues, N-acetylated)
• Molar Mass: approximately 3,108 g/mol
• Synonyms:
  • Tα1
  • Thymalfasin (INN)
• Vial Contents: 10 mg lyophilized powder
• Storage Recommendations:
  • Lyophilized powder: store at -4 °F (-20 °C) for long-term storage (stable for up to 3 years); short-term storage at 39 °F (4 °C) (up to 2 years). Keep sealed, dry, and away from light.
  • In solution: store at 39 °F (4 °C) for short periods, or at -4 °F (-20 °C) for longer durations. Avoid repeated freeze-thaw cycles. Use sterile technique when handling.

Certificate of Analysis (COA)

Every vial of Thymosin Alpha-1 offered by Evolve Peptides comes with a Certificate of Analysis (COA) to verify its identity, purity, and quality. These certificates are based on independent third-party testing, ensuring that each batch exceeds 99% purity and meets stringent analytical criteria for research applications.

Our COAs typically include:

• Purity analysis (e.g., HPLC or mass spectrometry)
• Identity confirmation
• Batch number and production date
• Storage conditions and solubility notes

You can access a sample COA PDF on each product page or request the specific COA for your batch after purchase. This documentation supports transparency and gives researchers confidence in the consistency and integrity of our products.

Legal Disclaimer

This product is intended strictly for laboratory research purposes only. It is not approved by the FDA or any other regulatory agency for human consumption, medical use, or veterinary application.

• • Not for diagnostic, therapeutic, or clinical use.
  • Not intended for resale or use in food, drugs, cosmetics, or household items.
• Not intended for ingestion, injection, or application to humans or animals, and should never be used in any form of self-experimentation.

By purchasing from Evolve Peptides, the buyer agrees to use it in accordance with all applicable laws, regulations, and research safety protocols.